Aglycon Ginsenoside (Careseng)
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For thousands of years, ginseng (Panax Quinquefolium L.) preparations have been used for health remedies. Careseng is related to this family of compounds.
Careseng contains the concentrated extract of several anti-cancer compounds found in ginseng, an herb with a long history of use in traditional Chinese medicine. Cell culture studies on breast, liver, colon, prostate, lung, pancreatic and brain cancer cells have shown that ginseng extract induces death (technically known as apoptosis) in cancer cells by impeding the growth of new blood vessels to cancer tumors. In low concentrations, Careseng was shown to stop cancer cells from growing and in high concentrations, Careseng caused cell death. Furthermore, when Careseng was combined with chemotherapy, such as Taxol, Cisplatin or Mitoxanthrone, the effectiveness of chemotherapy was enhanced.
Two preliminary clinical studies on Careseng also show a significant inhibition of cancer growth. What is more, no adverse side effects have been reported due to the use of Careseng.
The two main active anti-cancer agents in Careseng are Rh2 and a variety of plant compounds known as dammarane sapogenins, found especially in the araliaceae (a large family of mostly tropical shrubs and trees, of which ginseng is one). Cell culture studies of dammarane sapogenins demonstrate that in addition to inducing apoptosis, they can also inhibit cancer cell proliferation, induce differentiation of cancer cells into benign cells and block the function of a protein (P-glycoprotein) found in cancer cells, which is responsible for multi-drug resistance. Thus the efficacy of chemotherapy drugs is enhanced. There are also other possible anti-cancer effects.
